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Cytomegalovirus (CMV) retinitis is an opportunistic infection affecting immunocompromised patients. This case series describes 2 patients aged 19 and 10 years who were undergoing cancer treatment and were referred for complaints of worsening blurred vision. The retinal findings in the first patient showed multiple yellowish
subretinal areas with haemorrhages, while in the second patient there was presence of frosted branch angiitis. Confirmation of diagnosis was done using PCR of vitreous samples and blood CMV levels. Both tested negative for HIV. Both received intravitreal and systemic ganciclovir. It is important for ophthalmologists to consider CMV
retinitis in all patients with any form of immunosuppression.