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Differences in retinal ganglion cell layer and ganglion cell-inner plexiform layer thickness among haemodialysis patients with and without diabetes mellitus
- Denisa Rosati+−
- Sauli Ari Widjaja+−
- Ima Yustiarini+−
- Yulia Primitasari+−
- Artaria Tjempakasari+−
- Ria Sandy Deneska+−
- Ady Dwi Prakosa+−
- Muhammad Firmansjah+−
- Wimbo Sasono+−
Abstract
Introduction: This study aimed to compare the thickness of the retinal ganglion cell layer (GCL) and the ganglion cell-inner plexiform layer (GC-IPL) in haemodialysis (HD) patients with and without diabetes mellitus (DM).
Methods: This was a single-centre cross-sectional study conducted in Indonesia. Comprehensive ocular examinations and demographic information were gathered from 110 eyes of 110 HD patients. The sample was divided into DM and non-DM groups. Optical coherence tomography was used to analyse GCL and GC-IPL thickness. The independent t-test or Mann-Whitney test was used to examine the difference between the two groups, and a p-value of less than 0.05 was deemed significant.
Results: We analysed 110 eyes of 110 HD patients and divided them into the DM group (27, 24.5%) and non-DM group (83, 75.5%). The average duration of HD in the DM group was lower at 30.8 months than in the non-DM group of 50.6 months (p < 0.05). Hypertension was found in 24 (88.8%) patients in the DM group and 66 (79.5%) in the non-DM group (p < 0.05). HD patients with DM group showed significantly thinner GCL in all sectors (p < 0.05) and significantly thinner GC-IPL in 4 sectors (p < 0.05). In the hypertension cases, GCL and GC-IPL showed significant difference between the two groups (p < 0.05).
Conclusion: HD patients with DM demonstrated thinner GCL and GC-IPL. This finding indicates the importance of integrated ophthalmic evaluation in HD patients to prevent further damage of neural retina.