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Submitted: 2024-12-15
DOI: 10.35119/myjo.v8i2.445
Case Reports
Published: 2026-03-31

Exploring dedifferentiated orbital liposarcoma: a rare disease

Department of Ophthalmology, Hospital Kuala Lumpur, University Malaya Medical Centre Malaysia, Kuala Lumpur, Malaysia
Department of Pathology, Hospital Sultan Idris Shah, Serdang, Malaysia
Department of Pathology, University of Liverpool, Liverpool, United Kingdom
Department of Ophthalmology, University Malaya Medical Centre Malaysia, Kuala Lumpur, Malaysia
Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
Department of Ophthalmology, Hospital Sultan Idris Shah, Serdang, Malaysia
dedifferentiated liposarcoma proptosis orbital mass

Abstract

Background: To report a rare case of dedifferentiated liposarcoma.

Case presentation: A 72-year-old man presented with worsening proptosis of the right eye for 2 months, accompanied by severe pain and redness. He had a three-year history of progressive upper eyelid swelling in the right eye. His vision in the right eye deteriorated in 1 year to no light perception. The right eye displayed severe non-axial proptosis, with inferomedial displacement and rupture of the globe caused by a 95 x 90 x 30 mm mass. Computed tomography of the orbit revealed a heterogeneous mass with calcification occupying intra- and extraconal space, with inferomedial displacement of the indented globe. Biopsy of the orbital mass in the right eye showed acute inflammation with squamous metaplasia. The patient underwent a lid-sparing modified exenteration procedure. Histopathological examination revealed dedifferentiated liposarcoma.

Conclusion: Dedifferentiated orbital liposarcoma can be debilitating, particularly when accompanied with displacement of the eyeball.